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1p & 19q (FISH)

TEST NAME

– 1p & 19q (FISH)
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ABOUT TEST

– The gain/amplification CKS1B gene at chromosome region 1q21 (1q+) is one of the most common genetic aberrations in multiple myeloma (MM). CKS1Bamplification and overexpression contribute to increased p27Kip1 degradation, cell cycle upregulation and poor outcomes in MM patients. Amplification of CKS1B is frequently associated with the deletion of CDKN2C gene at chromosome region 1p32 (1p-). Deletion of CDKN2C, a tumor suppressor gene, leads to an increased proliferative rate of plasma cells in MM patients and is also associated with inferior outcomes. There are limited data on the impact of 1q+/1p- on the outcomes after high-dose therapy and autologous stem cell transplantation (auto-HCT).
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GENES TESTED


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SAMPLE REQUIREMENTS

– Green
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TAT

– 14
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Related Tests

– PCM FISH Panel (del(13q), del(17p), t(4;14), t(14;16), 1p/1q)FISH P53 (17p-), FISH t(4;14) and FISH t(14;16)
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