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Chronic Neutrophilic Leukemia (CSF3R gene; SETBP gene)

TEST NAME

– Chronic Neutrophilic Leukemia (CSF3R gene; SETBP gene)
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ABOUT TEST

– Chronic neutrophilic leukemia (CNL) is a distinct myeloproliferative neoplasm with a high prevalence (>80%) of mutations in the colony-stimulating factor 3 receptor (CSF3R). These mutations activate the receptor, leading to the proliferation of neutrophils that are a hallmark of CNL.
recent additional genomic characterization demonstrates that CNL has much in common with other chronic myeloid malignancies at the genetic level, such as the clinically related diagnosis atypical chronic myeloid leukemia. These commonalities include mutations in SETBP1, spliceosome proteins (SRSF2, U2AF1), and epigenetic modifiers (TET2, ASXL1).
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GENES TESTED


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SAMPLE REQUIREMENTS

– EDTA
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TAT

– 60
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Related Tests


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