TEST NAME
– HLA B27 (Molecular)
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ABOUT TEST
- The human leukocyte antigens (HLA) play a central role in the ability of the immune system to recognize self from non-self.
- There is a strong association between the HLA-B27 allele and ankylosing spondylitis (AS).
- AS is a debilitating, chronic, inflammatory condition characterized by lower back pain and stiffness, as well as arthritis in the spine, knees, hips,
and shoulders. - AS can result in inflammation and tissue damage in other organs, including the eyes, lungs, heart, and kidneys.
- Confirmation of diagnosis requires characteristic X-ray findings: blurring of bony margins of joints (in early stages), bilateral sacroiliac
involvement, patchy sclerosis with superficial bony erosions, eventual squaring of vertebral bodies and bamboo spine with complete ankylosis. - Diagnosis of AS is strongly suggested by typical symptoms, a positive family history, and presence of the HLA-B27 antigen.
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GENES TESTED
–
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SAMPLE REQUIREMENTS
– EDTA
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TAT
– 11
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Related Tests
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