TEST NAME
– Thrombophilia Panel
ــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــ
ABOUT TEST
– Hyperhomocysteinemia is an independent risk factor for coronary artery disease, acute MI, peripheral arterial disease, stroke, and VTE. Patients who are homozygous for the MTHFR C677T and A1298C mutations may develop hyperhomocysteinemia, especially with concurrent deficiency of vitamins B12, B6 (pyridoxine), or folic acid.
Beta-Fibrinogen (FGB) -455G>A: increases the risk for premature MI and ischemic stroke; confers elevated betafibrinogen plasma levels
PlasminogenActivatorInhibitor1(PAI-1,SerpinE1)4G/5G:The 4G allele is associated with higher PAI-1 transcription rates. It is considered to be a risk factor for VTE,MI and early pregnancy loss.
HumanPlateletAntigen1(HPA1a/b;GpIIIa;integrinb3L33P):HPA1b is a risk factor for early-onset MI and stroke,particularly in smokers.
Angiotensin-Converting Enzyme(ACE) 287bp insertion/deletion(I/D):represents a risk factor for MI in elder patients and in smokers; the D allele is associated with elevated ACE activity and plasma levels.
APO E gene:The major alleles are called E2, E3, and E4. The most common allele is E3, which is found in more than half of the general population.
The E4 version of the APO E gene increases an individual’s risk for developing late-onset Alzheimer disease and an increased chance of developing atherosclerosis and increased susceptibility to early-onset Myocardial infarction, while APOE E2 allele has been shown to greatly increase the risk of hyperlipoproteinemia type III.
ــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــ
GENES TESTED
– 16 genes
ــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــ
SAMPLE REQUIREMENTS
– EDTA
ــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــ
TAT
– 14
ــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــ
Related Tests
–
ــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــ