TEST NAME
– C-Myc oncogene (FISH)
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ABOUT TEST
– C-MYC Dual color, Break Apart Rearrangement probe is intended to detect chromosomal rearrangements involving the MYC gene region on chromosome 8q24. Translocations involving the MYC region have diagnostic and prognostic importance in B-cell malignancies. In Burkitts lymphoma, approximately 75% to 80% of cases carry t(8;14) IGH-MYC and the remainder are associated with t(8;22) IGL-MYC or t(2;8) IGK-MYC. In approximately 5-10% of diffuse large B-cell lymphoma (DLBCL) patients also have MYC region rearrangements, and detection of these rearrangements with the MYC rearrangement has been associated with poor prognosis.
Double-hit lymphomas are usually seen in the context of a complex karyotype containing multiple numerical and structural aberrations. Over 2/3 of cases demonstrate dual translocations involving 8q24/MYC and t(14;18)/BCL2 breakpoints. Less commonly the translocations implicate 8q24/MYC and 3q27/BCL6 sites and rare cases have breaks in all three sites, referred to a “triple hit” lymphoma.
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GENES TESTED
– 8q24 LSI C-MYC
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SAMPLE REQUIREMENTS
– Paraffin embedded tissue blocks
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TAT
– 14
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Related Tests
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