TEST NAME
– FISH 5q- (5q31;5q33)
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ABOUT TEST
– Deletions of chromosome 5q, or loss of the complete chromosome 5 are common abnormalities in MDS and AML. A commonly deleted segment on chromosome band 5q31 has been identified, and the early growth response 1 gene (EGR1) is among the candidate genes in this segment. For patients with MDS with isolated del(5q), prognoses vary widely. In those cases that fit the classic description of 5q- syndrome, the prognosis is favorable, with prolonged median survival and a lower rate of transformation to AML, as compared with other forms of MDS. Unlike 5q− syndrome, the presence of 5q deletions in high-risk subtypes of MDS and AML is an unfavorable prognostic factor, associated with rapid disease progression and poor outcome and survival. In AML, 5q deletion is usually associated with a complex karyotype and is also associated with poorer outcomes following treatment.
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GENES TESTED
– 5q31-5q33
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SAMPLE REQUIREMENTS
– Green
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TAT
– 14
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Related Tests
– FISH t(9;22) BCR/ABL and FISH 7q-
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SPECIALTIES
– Hematology, Hemato-Oncology